CDH17 Rabbit Polyclonal Antibody (ER1804-02)

UNIPROT #

Q12864

PROTEIN NAME

CDH17

SYNONYMS

BILL-cadherin antibody;CAD17_HUMAN antibody;Cadherin 16 antibody;Cadherin 16, formerly antibody;Cadherin 17 antibody;cadherin 17, LI cadherin (liver-intestine) antibody;cadherin, liver-intestine antibody;Cadherin-17 antibody;CDH16 antibody;CDH16, formerly antibody;Cdh17 antibody;FLJ26931 antibody;Formerly Cadherin 16 antibody;Formerly CDH16 antibody;HPT 1 antibody;HPT-1 cadherin antibody;human intestinal peptide-associated transporter HPT-1 antibody;human peptide transporter 1 antibody;Intestinal peptide-associated transporter HPT 1 antibody;Intestinal peptide-associated transporter HPT-1 antibody;LI-cadherin antibody;Liver Cadherin antibody;liver intestine cadherin antibody;Liver-intestine cadherin antibody

TISSUE SPECIFICITY

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.