Cdk2 Mouse Monoclonal Antibody [10-D7] (M1403-3)

UNIPROT #

P24941

PROTEIN NAME

Cdk2

SYNONYMS

Cdc2 related protein kinase antibody;cdc2-related protein kinase antibody;CDC28 antibody;CDC2A antibody;Cdk 2 antibody;CDK1 antibody;CDK2 antibody;CDK2_HUMAN antibody;CDKN2 antibody;Cell devision kinase 2 antibody;Cell division protein kinase 2 antibody;Cyclin dependent kinase 2 antibody;cyclin dependent kinase 2-alpha antibody;Cyclin-dependent kinase 2 antibody;kinase Cdc2 antibody;MPF antibody;p33 protein kinase antibody;p33(CDK2) antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.; Nitrosylated after treatment with nitric oxide (DETA-NO).

SUBCELLULAR LOCATION

Cytoplasm, nucleus

FUNCTION

Cyclin-dependent kinase 2 (p33CDK2) is an important component of the cell cycle machinery. It acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Inhibition of CDK2-cyclin complexes can also be attributed to association with p27 Kip1 and p21 Waf1/Cip1.