CDT2 Recombinant Rabbit Monoclonal Antibody [JE58-01] (HA721871)

UNIPROT #

Q9NZJ0

PROTEIN NAME

CDT2

SYNONYMS

Lethal(2) denticleless protein homolog antibody;CDW1 antibody;DCAF2 antibody;DDB1 and CUL4 associated factor 2 antibody;Ddb1- and Cul4-associated factor 2 antibody;Denticleless homolog antibody;Denticleless homolog (Drosophila) antibody;Denticleless protein homolog antibody;Dtl antibody;DTL_HUMAN antibody;L2DTL antibody;Lethal(2) denticleless protein homolog antibody;RA regulated nuclear matrix associated protein antibody;RAMP antibody;Retinoic acid regulated nuclear matrix associated protein antibody;Retinoic acid-regulated nuclear matrix-associated protein antibody

SUBCELLULAR LOCATION

Nucleus, Nucleus membrane, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Chromosome.

FUNCTION

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.