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CDX4 Rabbit Polyclonal Antibody (HA500489)

Price: Regular price $315.00

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Catalog# HA500489

Rabbit Polyclonal to CDX4

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

CDX4 Rabbit Polyclonal Antibody (HA500489)

Immunogen

Synthetic peptide within human cdx4 aa 50-100 / 284.

Host

Rabbit

Positive Control

Hela cell lysate, 293 cell lysate, rat cerebellum tissue, mouse testis tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071574

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:100-1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

31 kDa

Isotype

IgG

TARGET

UNIPROT #

O14627

PROTEIN NAME

CDX4

SYNONYMS

Caudal-type homeobox protein 4 antibody;CDX4 antibody;CDX4_HUMAN antibody;Homeobox protein CDX-4 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The transcription factor encoded by the CDX4 gene participates in the formation of extra-embryonic tissues, anterior-posterior patterning and blood formation during embryogenesis. It does so through the regulation of Hox gene expression. Before placentation takes place, CDX4 plays a role in its development. CDX4 mutants are born healthy and are fertile, however its importance is revealed in compound CDX mutants. Compound mutants carrying one CDX2 null allele and homozygous null for CDX4 fail to generate posterior tissue caudal to the hindlimbs and most of these embryos die around embryonic day 10.5 from lack of placental development. Around 10% of this phenotype may progress to full term, but then die shortly after birth. Upon inspection the morphogenesis of ano-rectal and urethral tissues was observed.

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