CELF1 Mouse Monoclonal Antibody [7A1] (EM1701-77)

UNIPROT #

Q92879

PROTEIN NAME

CELF1

SYNONYMS

50 kDa Nuclear polyadenylated RNA binding protein antibody;50 kDa nuclear polyadenylated RNA-binding protein antibody;Bruno like 2 antibody;bruno like protein 2 antibody;Bruno-like protein 2 antibody;BRUNOL 2 antibody;BRUNOL2 antibody;CELF 1 antibody;CELF-1 antibody;celf1 antibody;CELF1 CUGBP, Elav like family member 1 antibody;CELF1_HUMAN antibody;CUG BP and ETR 3 like factor 1 antibody;CUG BP antibody;CUG BP1 antibody;CUG RNA binding protein antibody;CUG triplet repeat RNA binding protein 1 antibody;CUG triplet repeat RNA-binding protein 1 antibody;CUG-BP antibody;CUG-BP- and ETR-3-like factor 1 antibody;CUG-BP1 antibody;CUGBP 1 antibody;CUGBP and ETR3 like factor 1 antibody;CUGBP antibody;CUGBP Elav like family member 1 antibody;CUGBP Elav-like family member 1 antibody;CUGBP1 antibody;Cytidine uridine guanosine binding protein 1 antibody;Deadenylation factor CUG BP antibody;Deadenylation factor CUG-BP antibody;Deadenylation factor CUGBP antibody;EDEN BP antibody;EDEN BP homolog antibody;EDEN-BP antibody;EDEN-BP homolog antibody;embryo deadenylation element binding protein antibody;embryo deadenylation element binding protein homolog antibody;Embryo deadenylation element-binding protein homolog antibody;hNab 50 antibody;hNab50 antibody;NAB 50 antibody;NAB50 antibody;NAPOR antibody;Nuclear polyadenylated RNA binding protein 50 kD antibody;Nuclear polyadenylated RNA binding protein antibody;RNA binding protein BRUNOL 2 antibody;RNA binding protein BRUNOL2 antibody;RNA-binding protein BRUNOL-2 antibody

SEQUENCE SIMILARITIES

Belongs to the CELF/BRUNOL family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Its phosphorylation status increases in senescent cells.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3'-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5' region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl.