CENPE Recombinant Rabbit Monoclonal Antibody [PSH03-54] (HA722013)

UNIPROT #

Q02224

PROTEIN NAME

CENPE

SYNONYMS

CENP E antibody;CENP-E antibody;CENPE antibody;CENPE_HUMAN antibody;Centromere associated protein E antibody;Centromere autoantigen E (312kD) antibody;Centromere autoantigen E antibody;Centromere protein E 312kDa antibody;Centromere protein E antibody;Centromere-associated protein E antibody;KIF10 antibody;Kinesin family member 10 antibody;Kinesin related protein antibody;Kinesin related protein CENPE antibody;Kinesin-related protein CENPE antibody;PPP1R61 antibody;Protein phosphatase 1, regulatory subunit 61 antibody

SUBCELLULAR LOCATION

Chromosome, centromere, kinetochore, Cytoplasm, cytoskeleton, spindle.

FUNCTION

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene. Centromere-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. CENPE is also called Kinesin-7. Mutations in CENPE result in autosomal recessive primary microcephaly type 13, which includes skeletal abnormalities and immunodeficiency.