Chromogranin A Mouse Monoclonal Antibody [A3H1] (HA600016)
Catalog# HA600016
Mouse Monoclonal to Chromogranin A
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WB
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IHC-P
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Human
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Mouse
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Rat
Specifications
Product Type
Mouse monoclonal primary
Product Name
Chromogranin A Mouse Monoclonal Antibody [A3H1] (HA600016)
Immunogen
Recombinant protein within human chromogranin a aa 358-457.
Host
Mouse
Positive Control
PC-12 cell lysates, mouse kidney tissue lysate, human small intestine tissue lysate, human pancreas tissue, rat pancreas tissue, mouse pancreas tissue, human medullary thyroid carcinoma tissue, human atypical carcinoid tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
A3H1
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IHC-P
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1:100-1:2,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2ug/ul
Purification
Protein G affinity purified.
Molecular Weight
Predicted band size: 51 kDa.
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Chromogranin A
SYNONYMS
beta Granin antibody;betagranin (N-terminal fragment of chromogranin A) antibody;catestatin antibody;CgA antibody;CHG A antibody;Chga antibody;chromofungin antibody;Chromogranin A antibody;Chromogranin A parathyroid secretory protein 1 antibody;Chromogranin A precursor antibody;ChromograninA antibody;CMGA_HUMAN antibody;ER-37 antibody;Pancreastatin antibody;Parastatin antibody;Parathyroid secretory protein 1 antibody;Pituitary secretory protein I antibody;Secretory protein I antibody;SP I antibody;SP-I antibody;SP1 antibody;SPI antibody;vasostatin 2 antibody;Vasostatin antibody;Vasostatin I antibody;Vasostatin II antibody;vasostatin-2 antibody
SUBCELLULAR LOCATION
Cytoplasmic vesicle, Secreted.
FUNCTION
Strongly inhibits glucose induced insulin release from the pancreas.Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa . Can induce mast cell migration, degranulation and production of cytokines and chemokines . Acts as a potent scavenger of free radicals in vitro tion and blood pressure .Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
CITATIONS
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Wu Lanxiang,et al
Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients
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IHC
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Mouse
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Citation
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