Chromogranin A Recombinant Mouse Monoclonal Antibody [D11-2-R] (HA601295)

UNIPROT #

P10645

PROTEIN NAME

Chromogranin A

SYNONYMS

beta Granin antibody;betagranin (N-terminal fragment of chromogranin A) antibody;catestatin antibody;CgA antibody;CHG A antibody;Chga antibody;chromofungin antibody;Chromogranin A antibody;Chromogranin A parathyroid secretory protein 1 antibody;Chromogranin A precursor antibody;ChromograninA antibody;CMGA_HUMAN antibody;ER-37 antibody;Pancreastatin antibody;Parastatin antibody;Parathyroid secretory protein 1 antibody;Pituitary secretory protein I antibody;Secretory protein I antibody;SP I antibody;SP-I antibody;SP1 antibody;SPI antibody;Vasostatin antibody;Vasostatin I antibody;Vasostatin II antibody

SUBCELLULAR LOCATION

Secreted. Secretory vesicle lumen.

FUNCTION

Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins. As such, it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in the pancreas. In humans, chromogranin A protein is encoded by the CHGA gene. Chromogranin A is the precursor to several functional peptides including vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). Chromogranin A induces and promotes the generation of secretory granules such as those containing insulin in pancreatic islet beta cells.