Chromogranin A Rabbit Polyclonal Antibody (ER40724)
Catalog# ER40724
Rabbit Polyclonal to Chromogranin A
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WB
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IHC-P
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FC
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IF-Tissue
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IF-Cell
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Human
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Mouse
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
Chromogranin A Rabbit Polyclonal Antibody (ER40724)
Immunogen
Synthetic peptide corresponding to c-terminal of mouse chromogranin a aa 408-457 / 457 (id: p10645).
Host
Rabbit
Positive Control
PC12 cell lysate, human pancreas tissue, mouse pancreas tissue, rat pancreas tissue, human colon cancer tissue, Lovo.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:2,000
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IHC-P
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1:200-1:1,000
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FC
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1:100-1:200
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IF-Tissue
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1:200
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IF-Cell
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1:100
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 52 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Chromogranin A
SYNONYMS
CISY_HUMAN antibody;Citrate synthase antibody;Citrate synthase, mitochondrial antibody;citrate synthetase antibody;Cs antibody;EC 2.3.3 antibody;EC 2.3.3.1 antibody
SEQUENCE SIMILARITIES
Belongs to the chromogranin/secretogranin protein family.
POST-TRANSLATIONAL MODIFICATION
CgA is O-glycosylated.
SUBCELLULAR LOCATION
Cytoplasmic vesicle, secreted.
FUNCTION
Chromogranin A is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). Chromogranin A might promote the generation of secretory granules. It is used as an indicator for pancreas and prostate cancer. It might play a role in early neoplasic progression. It is also elevated in diabetes.
CITATIONS
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Li, B., Cheng, Y., Yin, Y., Xue, J., Yu, S., Gao, J., Liu, J., Zang, L., & Mu, Y.
Reversion of early- and late-stage β-cell dedifferentiation by human umbilical cord-derived mesenchymal stem cells in type 2 diabetic mice
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IF
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Mouse
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Citation
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