Cleaved PARP Recombinant Rabbit Monoclonal Antibody [SU0314] (ET1608-10)

Apatinib Inhibits Bladder Cancer through Suppression of the VEGFR2-PI3K-AKT Signaling Pathway as Revealed by Network Pharmacology and in vitro Experimental Verification

Ren Yanlin,et al

Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction

Reduced HMGB1 expression contributed to lapatinib-induced cutaneous injury

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Network-based pharmacology and in vitro validation reveal that galangin induces apoptosis in bladder cancer cells by promoting the p53 signaling pathway

Disulfiram enhances the antitumor activity of cisplatin by inhibiting the Fanconi anemia repair pathway

Tao Xinyu,et al

Dabrafenib Alleviates Hepatotoxicity Caused by Lenvatinib via Inhibiting the Death Receptor Signaling Pathway

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Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis

Yuan, T., Wu, R., Wang, W., Liu, Y., Kong, W., Yang, B., He, Q., & Zhu, H.

Synergistic antitumor activity of regorafenib and rosuvastatin in colorectal cancer

Weng, Q., Sun, H., Fang, C., Xia, F., Liao, H., Lee, J., Wang, J., Xie, A., Ren, J., Guo, X., Li, F., Yang, B., & Ling, D.

Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics. Nature communications, 12(1), 1436.

Shao, C., Yu, Z., Luo, T., Zhou, B., Song, Q., Li, Z., Yu, X., Jiang, S., Zhou, Y., Dong, W., Zhou, X., Wang, X., & Song, H.

Chitosan-Coated Selenium Nanoparticles Attenuate PRRSV Replication and ROS/JNK-Mediated Apoptosis in vitro

Pang Dejiang,et al

The Long Non-Coding RNA NR3C2-8: 1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis

Hu Xin,et al

Screening of anti-melanoma compounds from Morus alba L.: Sanggenon C promotes melanoma cell apoptosis by disrupting intracellular Ca2+ homeostasis

Zhou Tong,et al

Metformin overcomes chemoresistance by regulating stemness via KLF4 in oral squamous cell carcinoma

Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation

Zhao Lili,et al

hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under mitochondrial stress

Discovery of Novel 1,2,3,4-Tetrahydrobenzofuro[2,3-c]pyridine Histone Deacetylase Inhibitors for Efficient Treatment of Hepatocellular Carcinoma

Zhou Heng,et al

Modulation of epithelial-mesenchymal transition by gemcitabine: Targeting ionizing radiation-induced cellular senescence in lung cancer cell

Hu Yinqun,et al

Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway

Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis

Crizotinib induces pulmonary toxicity by blocking autophagy flux in alveolar epithelial cells

Hu, J., Cao, J., Jin, R., Zhang, B., Topatana, W., Juengpanich, S., Li, S., Chen, T., Lu, Z., Cai, X., & Chen, M.

Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth

Heng Zhou,et al

The role of apoptosis, immunogenic cell death, and macrophage polarization in carbon ion radiotherapy for keloids: Targeting the TGF-β1/SMADs signaling pathway

Dasatinib causes keratinocyte apoptosis via inhibiting high mobility group Box 1-mediated mitophagy

Chloroquine Intervenes Nephrotoxicity of Nilotinib through Deubiquitinase USP13‐Mediated Stabilization of Bcl‐XL

Chaetocin exhibits anticancer effects in esophageal squamous cell carcinoma via activation of Hippo pathway

Chen, X. B., Zhu, H. Y., Bao, K., Jiang, L., Zhu, H., Ying, M. D., He, Q. J., Yang, B., Sheng, R., & Cao, J.

Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors. Acta pharmacologica Sinica, 10.1038/s41401-020-00600-5. Advance online publication.

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Evodiamine Inhibits the Progression of Esophageal Aquamous Cell Carcinoma via Modulating PI3K/AKT/mTOR Pathway

Dr Xia Liu,Professor Jianchao Wang

Silencing RRM2 inhibits multiple myeloma by targeting the Wnt/β-catenin signaling pathway

Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling Pathway

Fu Lina,et al

Exploring the Potential of Thiophene Derivatives as Dual Inhibitors of β-Tubulin and Wnt/β-Catenin Pathways for Gastrointestinal Cancers in Vitro

Elucidation of the anti-colon cancer mechanism of Phellinus baumii polyphenol by an integrative approach of network pharmacology and experimental verification

Qing-yong Hu,et al

A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth

Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib

Liu, X., Cui, S., Dan, C., Li, W., Xie, H., Li, C., & Shi, L.

Phellinus baumii Polyphenol: A Potential Therapeutic Candidate against Lung Cancer Cells

Chen, Y., Lu, Z., Qi, C., Yu, C., Li, Y., Huan, W., Wang, R., Luo, W., Shen, D., Ding, L., Ren, L., Xie, H., Xue, D., Wang, M., Ni, K., Xia, L., Qian, J., & Li, G.

N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma