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COPS8 Rabbit Polyclonal Antibody (ER2001-29)

Price: Regular price $315.00

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Catalog# ER2001-29

Rabbit Polyclonal to COPS8

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

COPS8 Rabbit Polyclonal Antibody (ER2001-29)

Immunogen

Recombinant protein within human cops8 aa 1-300.

Host

Rabbit

Positive Control

SHSY5Y cell lysate, HL-60 cell lysate, rat brain tissue, rat cerebellum tissue, human liver tissue, human liver carcinoma tissue, mouse brain tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069507

APPLICATION DILUTION

  • WB:1:500-1:1,000

  • IHC-P

  • 1:100-1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 23 kDa.

Isotype

IgG

TARGET

UNIPROT #

Q99627

PROTEIN NAME

COPS8

SYNONYMS

COP9 homolog antibody;COP9 signalosome complex subunit 8 antibody;COP9 signalosome subunit 8 antibody;Cops8 antibody;CSN8 antibody;CSN8_HUMAN antibody;hCOP9 antibody;JAB1 containing signalosome subunit 8 antibody;JAB1-containing signalosome subunit 8 antibody;SGN8 antibody;Signalosome subunit 8 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Signalosome.

FUNCTION

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

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