Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31] (ET7108-47)

UNIPROT #

Q13617

PROTEIN NAME

Cullin 2

SYNONYMS

Cul2 antibody;CUL 2 antibody;CUL-2 antibody;CUL2 antibody;CUL2_HUMAN antibody;cullin 2 antibody;cullin homolog 2 antibody;Cullin-2 antibody;MGC131970 antibody

SEQUENCE SIMILARITIES

Belongs to the cullin family.

POST-TRANSLATIONAL MODIFICATION

Neddylated; which enhances the ubiquitination activity of ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes. CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Cullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/CUL-1/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex.