CX3CL1 Rabbit Polyclonal Antibody (HA500304)

UNIPROT #

P78423

PROTEIN NAME

CX3CL1

SYNONYMS

A 152E5.2 antibody;AB030188 antibody;ABCD 3 antibody;ABCD3 antibody;AI848747 antibody;C-X3-C motif chemokine 1 antibody;C3Xkine antibody;Chemokine (C-X3-C motif) ligand 1 antibody;Chemokine C X3 C motif ligand 1 antibody;Chemokine CX3C Motif Ligand 1 antibody;CX3C membrane anchored chemokine antibody;CX3C membrane-anchored chemokine antibody;Cx3cl1 antibody;CXC 3 antibody;CXC3 antibody;CXC3C antibody;D8Bwg0439e antibody;FKN antibody;Fractalkine antibody;Neurotactin antibody;NTN antibody;NTT antibody;Processed fractalkine antibody;SCYD 1 antibody;SCYD1 antibody;Small inducible cytokine D1 antibody;Small inducible cytokine subfamily D (Cys X3 Cys) member 1 antibody;small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin) antibody;Small inducible cytokine subfamily D member 1 antibody;Small-inducible cytokine D1 antibody;X3CL1_HUMAN antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane, Secreted.

FUNCTION

Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 . Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 . The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium.