CXCR3 Recombinant Rabbit Monoclonal Antibody [JA61-33] (ET1704-97)

UNIPROT #

P49682

PROTEIN NAME

CXCR3

SYNONYMS

C-X-C chemokine receptor type 3 antibody;CD 183 antibody;CD182 antibody;CD183 antibody;Chemokine (C X C motif) receptor 3 antibody;Chemokine (C X C) receptor 3 antibody;Chemokine CXC Motif Receptor 3 antibody;CKR L2 antibody;CKR-L2 antibody;CKRL2 antibody;CMKAR3 antibody;CXC-R3 antibody;CXCR-3 antibody;CXCR3 antibody;CXCR3_HUMAN antibody;G Protein Coupled Receptor 9 antibody;G protein-coupled receptor 9 antibody;GPR9 antibody;Interferon-inducible protein 10 receptor antibody;IP-10 receptor antibody;IP10 antibody;IP10 R antibody;IP10 receptor antibody;IP10-R antibody;IP10R antibody;Mig R antibody;Mig receptor antibody;Mig-R antibody;MIGR antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.; N-glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. CXCR3 is able to regulate leukocyte trafficking. Binding of chemokines to CXCR3 induces various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration. CXCR3-ligand interaction attracts Th1 cells and promotes Th1 cell maturation. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. A hallmark of CXCR3 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, CXCL9, CXCL10 and CXCL11 are commonly produced by local cells in inflammatory lesion, suggesting that CXCR3 and its chemokines participate in the recruitment of inflammatory cells. Additionally, CXCR3 has been implicated in wound healing.