CYP26A1 Recombinant Rabbit Monoclonal Antibody [JG33-98] (ET7108-02)

UNIPROT #

O43174

PROTEIN NAME

CYP26A1

SYNONYMS

CP26 antibody;CP26A_HUMAN antibody;CYP26 antibody;CYP26A 1 antibody;cyp26a1 antibody;Cytochrome P450 26A1 antibody;Cytochrome P450 family 26 subfamily A polypeptide 1 antibody;Cytochrome P450 retinoic acid-inactivating 1 antibody;cytochrome P450, family 26, subfamily A, polypeptide 1 antibody;cytochrome P450, subfamily XXVIA, polypeptide 1 antibody;Cytochrome P450RAI antibody;hP450RAI antibody;OTTHUMP00000020102 antibody;OTTHUMP00000020103 antibody;P450 antibody;P450 retinoic acid inactivating 1 antibody;P450RAI antibody;P450RAI1 antibody;Retinoic acid 4 hydroxylase antibody;Retinoic acid 4-hydroxylase antibody;Retinoic acid metabolizing cytochrome antibody;Retinoic acid-metabolizing cytochrome antibody

SEQUENCE SIMILARITIES

Belongs to the cytochrome P450 family.

TISSUE SPECIFICITY

Expressed in most fetal and adult tissues with highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain. Expressed at high levels in lung, pancreas, skin and uterus (at protein level). Lower expression level is detected in spleen, kidney, intestine and adipose tissue (at protein level).

SUBCELLULAR LOCATION

Endoplasmic reticulum, Membrane, Microsome.

FUNCTION

The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1, also referred to as retinoic acid-4-hydroxylase, is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor β2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.