Cytochrome P450 1A2 Recombinant Rabbit Monoclonal Antibody [JE39-22] (HA721495)

UNIPROT #

P05177

PROTEIN NAME

Cytochrome P450 1A2

SYNONYMS

Aryl hydrocarbon hydroxylase antibody;CP 12 antibody;CP12 antibody;CP1A2_HUMAN antibody;CYP1A2 antibody;CYPIA2 antibody;Cytochrome P(3)450 antibody;Cytochrome P450 1A2 antibody;Cytochrome P450 4 antibody;Cytochrome P450 family 1 polypeptide 2 antibody;Cytochrome P450 family 1 subfamily A polypeptide 2 antibody;Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2 antibody;Cytochrome P450-P3 antibody;Cytochrome P4501A2 antibody;Dioxin inducable P3 450 antibody;Flavoprotein linked monooxygenase antibody;Flavoprotein-linked monooxygenase antibody;Microsomal monooxygenase antibody;P(3)450 antibody;P3 450 antibody;P450 4 antibody;P450 form 4 antibody;P450 P3 antibody;P450(PA) antibody;Xenobiotic monooxygenase antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Microsome membrane.

FUNCTION

Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene. CYP1A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and paracetamol (acetaminophen). The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.