Cytokeratin 1 Recombinant Rabbit Monoclonal Antibody [SN72-08] (ET1611-46)

UNIPROT #

P04264

PROTEIN NAME

Cytokeratin 1

SYNONYMS

67 kDa cytokeratin antibody;CK-1 antibody;CK1 antibody;Cytokeratin-1 antibody;Cytokeratin1 antibody;EHK antibody;EHK1 antibody;Epidermolytic hyperkeratosis 1 antibody;EPPK antibody;Hair alpha protein antibody;K1 antibody;K2C1_HUMAN antibody;Keratin antibody;Keratin type II cytoskeletal 1 antibody;Keratin-1 antibody;Keratin1 antibody;KRT 1 antibody;Krt1 antibody;KRT1A antibody;NEPPK antibody;type II cytoskeletal 1 antibody;Type II keratin Kb1 antibody;Type-II keratin Kb1 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.

POST-TRANSLATIONAL MODIFICATION

Undergoes deimination of some arginine residues (citrullination).

SUBCELLULAR LOCATION

Cell membrane, Intermediate filament, Keratin, Membrane.

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.