Cytokeratin 18 Mouse Monoclonal Antibody [6-19] (M0407-19)

UNIPROT #

P05783

PROTEIN NAME

Cytokeratin 18

SYNONYMS

Cell proliferation inducing gene 46 protein antibody;Cell proliferation inducing protein 46 antibody;Cell proliferation-inducing gene 46 protein antibody;CK 18 antibody;CK-18 antibody;CK18 antibody;CYK 18 antibody;CYK18 antibody;Cytokeratin 18 antibody;Cytokeratin endo B antibody;Cytokeratin-18 antibody;K 18 antibody;K18 antibody;K1C18_HUMAN antibody;KA18 antibody;Keratin 18 antibody;Keratin 18, type I antibody;Keratin D antibody;keratin, type I cytoskeletal 18 antibody;Keratin-18 antibody;Krt18 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.; Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.; O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.