Cytokeratin 18 Rabbit Polyclonal Antibody (0407-1)

UNIPROT #

P05783

PROTEIN NAME

Cytokeratin 18

SYNONYMS

Cell proliferation inducing gene 46 protein antibody;Cell proliferation inducing protein 46 antibody;Cell proliferation-inducing gene 46 protein antibody;CK 18 antibody;CK-18 antibody;CK18 antibody;CYK 18 antibody;CYK18 antibody;Cytokeratin 18 antibody;Cytokeratin endo B antibody;Cytokeratin-18 antibody;K 18 antibody;K18 antibody;K1C18_HUMAN antibody;KA18 antibody;Keratin 18 antibody;Keratin 18, type I antibody;Keratin D antibody;keratin, type I cytoskeletal 18 antibody;Keratin-18 antibody;Krt18 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.; Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.; O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm, perinuclear region.

FUNCTION

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.