DDX17 Recombinant Rabbit Monoclonal Antibody [JE35-01] (HA721493)

UNIPROT #

Q92841

PROTEIN NAME

DDX17

SYNONYMS

Ddx17 antibody;DDX17_HUMAN antibody;DEAD (Asp Glu Ala Asp) box helicase 17 antibody;DEAD (Asp Glu Ala Asp) box polypeptide 17 antibody;DEAD box helicase 17 antibody;DEAD box protein 17 antibody;DEAD box protein p72 antibody;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 17 antibody;P72 antibody;Probable ATP-dependent RNA helicase DDX17 antibody;RH70 antibody;RNA dependent helicase p72 antibody;RNA-dependent helicase p72 antibody

SUBCELLULAR LOCATION

Nucleus, nucleolus, Cytoplasm, cytosol.

FUNCTION

Probable ATP-dependent RNA helicase DDX17 (p72) is an enzyme that in humans is encoded by the DDX17 gene. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species but not by dsDNA. This protein and that encoded by DDX5 gene are more closely related to each other than to any other member of the DEAD box family. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms with the longer transcript reported to also initiate translation at a non-AUG (CUG) start site.