DDX5 Recombinant Rabbit Monoclonal Antibody [JM32-50] (ET1705-32)

UNIPROT #

P17844

PROTEIN NAME

DDX5

SYNONYMS

ATP dependent RNA helicase DDX5 antibody;DDX 5 antibody;Ddx5 antibody;DDX5_HUMAN antibody;DEAD (Asp Glu Ala Asp) box helicase 5 antibody;DEAD (Asp Glu Ala Asp) box polypeptide 5 antibody;DEAD box 5 antibody;DEAD box protein 5 antibody;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase, 68kD) antibody;G17P1 antibody;HELR antibody;HLR1 antibody;HUMP68 antibody;P68 antibody;p68 RNA helicase antibody;Probable ATP dependent RNA helicase DDX5 antibody;Probable ATP-dependent RNA helicase DDX5 antibody;RNA helicase p68 antibody

SEQUENCE SIMILARITIES

Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

POST-TRANSLATIONAL MODIFICATION

Arg-502 is dimethylated, probably to asymmetric dimethylarginine.; Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination.; Polyubiquitinated, leading to proteasomal degradation.; Weakly phosphorylated in the G1/S phase of the cell cycle and much more at G2/M, especially at Thr and Tyr residues.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.