Desmin Recombinant Rabbit Monoclonal Antibody [SI18-00] (ET1606-30)

UNIPROT #

P17661

PROTEIN NAME

Desmin

SYNONYMS

CMD1I antibody;CSM1 antibody;CSM2 antibody;DES antibody;DESM_HUMAN antibody;Desmin antibody;FLJ12025 antibody;FLJ39719 antibody;FLJ41013 antibody;FLJ41793 antibody;Intermediate filament protein antibody;OTTHUMP00000064865 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

POST-TRANSLATIONAL MODIFICATION

ADP-ribosylation prevents ability to form intermediate filaments.; Phosphorylation at Ser-7, Ser-28 and Ser-32 by CDK1, phosphorylation at Ser-60 by AURKB and phosphorylation at Thr-76 by ROCK1 contribute to efficient separation of desmin intermediate filaments during mitosis.

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane.

FUNCTION

Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Desmin makes up attachments between the terminal Z-disc and membrane-associated proteins to form a force-transmitting system. Mutations in the gene encoding for Desmin are associated with adult-onset skeletal myopathy, sporadic disease and mild cardiac involvement.