DGCR8 Recombinant Rabbit Monoclonal Antibody [ST04-79] (ET1609-32)

UNIPROT #

Q8WYQ5

PROTEIN NAME

DGCR8

SYNONYMS

DGCRK6 antibody;C22orf12 antibody;D16H22S788E antibody;D16Wis2 antibody;DGCR 8 antibody;Dgcr8 antibody;DGCR8 microprocessor complex subunit antibody;DGCR8_HUMAN antibody;DGCRK 6 antibody;DiGeorge syndrome critical region 8 antibody;DiGeorge syndrome critical region gene 8 antibody;Gy1 antibody;Microprocessor complex subunit DGCR8 antibody;pasha antibody

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Nucleus, cytoplasm.

FUNCTION

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding.Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing.Involved in the silencing of embryonic stem cell self-renewal.