DMAP1 Recombinant Rabbit Monoclonal Antibody [JE55-31] (HA722002)

UNIPROT #

Q9NPF5

PROTEIN NAME

DMAP1

SYNONYMS

DKFZp686L09142 antibody;DMAP 1 antibody;DMAP1 antibody;DMAP1_HUMAN antibody;DNA methyltransferase 1 associated protein 1 antibody;DNA methyltransferase 1-associated protein 1 antibody;DNMAP 1 antibody;DNMAP1 antibody;DNMT1 associated protein 1 antibody;DNMT1-associated protein 1 antibody;DNMTAP 1 antibody;DNMTAP1 antibody;EAF 2 antibody;EAF2 antibody;FLJ11543 antibody;KIAA1425 antibody;MAT 1 mediated transcriptional repressor antibody;MGC55593 antibody;SWC 4 antibody;SWC4 antibody;zgc:55593 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

DNA methyltransferase 1-associated protein 1 is an enzyme that in humans is encoded by the DMAP1 gene. This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.