DNMT3L Mouse Monoclonal Antibody [B0-5] (M1405-4)

UNIPROT #

Q9UJW3

PROTEIN NAME

DNMT3L

SYNONYMS

Cytosine 5 methyltransferase 3 like protein antibody;DNA (cytosine 5 ) methyltransferase 3 like antibody;DNA (cytosine-5)-methyltransferase 3-like antibody;DNA cytosine 5 methyltransferase 3 like protein antibody;DNA methyltransferase 3 like protein antibody;DNM3L_HUMAN antibody;Dnmt 3L antibody;Dnmt3l antibody;Human cytosine 5 methyltransferase 3 like protein antibody;MGC1090 antibody

TISSUE SPECIFICITY

Expressed at low levels in several tissues including testis, ovary, and thymus.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1.