DOK1 Recombinant Rabbit Monoclonal Antibody [JE54-52] (ET7110-75)

UNIPROT #

Q99704

PROTEIN NAME

DOK1

SYNONYMS

Docking protein 1 62kD antibody;Docking protein 1 antibody;DOK 1 antibody;DOK1 antibody;DOK1_HUMAN antibody;Downstream of tyrosine kinase 1 antibody;p62(dok) antibody;P62DOK antibody;pp62 antibody

SEQUENCE SIMILARITIES

Belongs to the DOK family. Type A subfamily.

TISSUE SPECIFICITY

Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.

POST-TRANSLATIONAL MODIFICATION

Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.

SUBCELLULAR LOCATION

Nucleus, cytoplasm; Perinuclear region.

FUNCTION

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene. The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.