DRD1 Recombinant Rabbit Monoclonal Antibody [JM10-93] (ET1703-45)
Catalog# ET1703-45
Rabbit Monoclonal to DRD1
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WB
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IF-Cell
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IF-Tissue
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IHC-P
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Human
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Mouse
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Rat
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
DRD1 Recombinant Rabbit Monoclonal Antibody [JM10-93] (ET1703-45)
Immunogen
Synthetic peptide within c-terminal human drd1.
Host
Rabbit
Positive Control
Mouse brain tissue lysate, Rat brain tissue lysate, 293T, N2A, SH-SY5Y, mouse brain tissue, rat brain tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JM10-93
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IF-Cell
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1:100-1:500
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IF-Tissue
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1:100-1:500
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 49 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
DRD1
SYNONYMS
D(1A) dopamine receptor antibody;D1A dopamine receptor antibody;DADR antibody;Dopamine D1 receptor antibody;dopamine receptor D1 antibody;DR D1 antibody;DR D1A antibody;DRD 1 antibody;DRD 1A antibody;DRD1 antibody;DRD1_HUMAN antibody;DRD1A antibody
SEQUENCE SIMILARITIES
Belongs to the G-protein coupled receptor 1 family.
TISSUE SPECIFICITY
Detected in caudate, nucleus accumbens and in the olfactory tubercle.
SUBCELLULAR LOCATION
Cell membrane. Endoplasmic reticulum membrane.
FUNCTION
The members of the G protein coupled receptor family are distinguished by their slow transmitting response to ligand binding. These transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. β-adrenergic receptor binds to adrenaline activates adenylyl cyclase, while α2-adrenergic receptor binds to adrenaline inhibits adenylyl cyclase. The dopamine receptors are divided into two classes, D1 and D2, which differ in their functional characteristics in that D1 receptors stimulate adenylyl cyclase while D2 receptors inhibit adenylyl cyclase activity. Five different subtypes of dopamine receptor have been described to date. D1DR and D5DR belong to the D1 subclass, while D2DR, D3DR and D4DR belong to the D2 subclass.
CITATIONS
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Li, X., Xiao, Z., Pu, W., Jiang, Z., Wang, S., & Zhang, Y.
Network pharmacology, molecular docking, and experimental validation to explore the potential mechanism of Long Mu Qing Xin mixture for the treatment of attention deficit hyperactivity disorder
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IHC
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Rat
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Citation
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