DUSP6 Recombinant Rabbit Monoclonal Antibody [SR39-09] (ET1602-18)

UNIPROT #

Q16828

PROTEIN NAME

DUSP6

SYNONYMS

Dual specificity phosphatase 6 antibody;Dual specificity phosphatase 6 isoform a antibody;Dual specificity protein phosphatase 6 antibody;Dual specificity protein phosphatase PYST1 antibody;DUS6_HUMAN antibody;DUSP 6 antibody;DUSP 6a antibody;Dusp6 antibody;DUSP6a antibody;HH19 antibody;MAP kinase phosphatase 3 antibody;Mitogen activated protein kinase phosphatase 3 antibody;Mitogen-activated protein kinase phosphatase 3 antibody;MKP 3 antibody;MKP-3 antibody;MKP3 antibody;PYST 1 antibody;PYST1 antibody;Serine/threonine specific protein phosphatase antibody

SEQUENCE SIMILARITIES

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

TISSUE SPECIFICITY

Expressed in keratinocytes (at protein level).

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. Upregulation of MKP-3 has been shown to alleviate chronic postoperative pain.