EEA1 Mouse Monoclonal Antibody [B0-A8] (M1503-1)

UNIPROT #

Q15075

PROTEIN NAME

EEA1

SYNONYMS

Early endosome antigen 1 antibody;Early endosome antigen 1, 162kD antibody;Early endosome associated protein antibody;EEA 1 antibody;EEA1 antibody;EEA1_HUMAN antibody;Endosome associated protein p162 antibody;Endosome-associated protein p162 antibody;MST105 antibody;MSTP105 antibody;ZFYVE2 antibody;Zinc finger FYVE domain containing protein 2 antibody;Zinc finger FYVE domain-containing protein 2 antibody

SUBCELLULAR LOCATION

Cytoplasm, early endosome membrane.

FUNCTION

EEA1 localizes exclusively to early endosomes?and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate?through its C-terminalFYVE domain?and forms a homodimer?through a?coiled coil. EEA1 acts as a tethering molecule that couples vesicle docking with SNAREs such as?N-ethylmaleimide sensitive fusion protein, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo. Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the vacuole.Mycobacterium tuberculosis?is known to inhibit the recruitment of EEA1 to the phagosomal membrane through CamKII. Legionella pneumophila?also prevents EEA1 recruitment through a currently unknown mechanism.[5] Interestingly, the related pathogen Legionella longbeachae?recruits EEA1 and appears to replicate within a modified early endosome.