EIF2S1 Rabbit Polyclonal Antibody (HA500385)

UNIPROT #

P05198

PROTEIN NAME

EIF2S1

SYNONYMS

EIF 2 alpha antibody;EIF 2 antibody;EIF 2A antibody;EIF 2alpha antibody;eIF-2-alpha antibody;eIF-2A antibody;EIF-2alpha antibody;EIF2 alpha antibody;EIF2 antibody;EIF2A antibody;EIF2S1 antibody;Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa antibody;Eukaryotic translation initiation factor 2 subunit 1 alpha antibody;Eukaryotic translation initiation factor 2 subunit 1 antibody;Eukaryotic translation initiation factor 2 subunit alpha antibody;IF2A_HUMAN antibody

SUBCELLULAR LOCATION

Stress granule.

FUNCTION

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming.