eIF3A Recombinant Rabbit Monoclonal Antibody [JE58-60] (HA721375)

UNIPROT #

Q14152

PROTEIN NAME

eIF3A

SYNONYMS

centrosomin homolog antibody;cytoplasmic protein p167 antibody;eIF 3 theta antibody;eIF-3-theta antibody;EIF3 antibody;eIF3 p167 antibody;eIF3 p170 antibody;eIF3 p180 antibody;EIF3 p180 subunit antibody;eIF3 p185 antibody;eIF3 theta antibody;eIF3a antibody;EIF3A_HUMAN antibody;EIF3S10 antibody;eukaryotic translation initiation factor 3 subunit 10 (theta 150 170kD) antibody;eukaryotic translation initiation factor 3 subunit 10 (theta 170kD) antibody;eukaryotic translation initiation factor 3 subunit 10 170kDa antibody;Eukaryotic translation initiation factor 3 subunit 10 antibody;eukaryotic translation initiation factor 3 subunit 10 theta 150 170kDa antibody;Eukaryotic translation initiation factor 3 subunit A antibody;OTTHUMP00000020589 antibody;P167 antibody;p180 antibody;p185 antibody;TIF32 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.