eIF3e Recombinant Rabbit Monoclonal Antibody [JE53-63] (ET7110-40)

UNIPROT #

P60228

PROTEIN NAME

eIF3e

SYNONYMS

eIF-3 p48 antibody;eIF3e antibody;EIF3E_HUMAN antibody;EIF3S6 antibody;eIFe antibody;Eukaryotic translation initiation factor 3 subunit 6 antibody;Eukaryotic translation initiation factor 3 subunit E antibody;eukaryotic translation initiation factor 3, subunit 6 (48kD) antibody;INT6 antibody;mammary tumor-associated protein INT6 antibody;murine mammary tumor integration site 6 (oncogene homolog) antibody;Viral integration site protein INT-6 homolog antibody

SEQUENCE SIMILARITIES

Belongs to the eIF-3 subunit E family.

TISSUE SPECIFICITY

Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.