ERAP1 Recombinant Rabbit Monoclonal Antibody [JE52-36] (ET7110-29)

UNIPROT #

Q9NZ08

PROTEIN NAME

ERAP1

SYNONYMS

A LAP antibody;A-LAP antibody;Adipocyte derived leucine aminopeptidase antibody;Adipocyte-derived leucine aminopeptidase antibody;ALAP antibody;Aminopeptidase PILS antibody;Aminopeptidase regulator of TNFR1 shedding antibody;APPILS antibody;ARTS 1 antibody;ARTS-1 antibody;Arts1 antibody;Endoplasmic reticulum aminopeptidase 1 antibody;Endoplasmic reticulum aminopeptidase associated with antigen processing antibody;ERAAP antibody;ERAAP1 antibody;ERAP 1 antibody;Erap1 antibody;ERAP1_HUMAN antibody;KIAA0525 antibody;kiaa0525 protein antibody;PILS AP antibody;PILS-AP antibody;PILSA antibody;PILSAP antibody;Puromycin insensitive leucyl specific aminopeptidase antibody;Puromycin-insensitive leucyl-specific aminopeptidase antibody;Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator antibody;type 1 tumor necrosis factor receptors shedding aminopeptidase regulator antibody;VEGF-induced aminopeptidase antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M1 family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is localized to the lumen of the ER, which removes NH2-terminal residues from many antigenic precursors for MHC class I peptide presentation. ERAP1 is also designated adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1). Peptides presented by MHC class I on the surface of a cell must be eight to eleven residues long and ERAP1 specifically trims peptides of nine amino acids or more. ERAP1 is induced by interferon-g and encoded for by the ARTS1 gene, which maps to human chromosome 5q15. ERAP1 is thought to inactivate several bioactive peptides, including angioten-sin II, and subsequently, may be involved in the regulation of blood pressure. It may have a role in angiogenesis by regulating the proliferation and migration of endothelial cells, and is characterized as a TNFR1 binding protein that promotes TNFR1 shedding.