EWSR1/EWS Recombinant Rabbit Monoclonal Antibody [JE49-57] (ET7109-94)

UNIPROT #

Q01844

PROTEIN NAME

EWSR1/EWS

SYNONYMS

bK984G1.4 antibody;bK984G1.4 Ewing sarcoma breakpoint region 1 protein antibody;Ewing sarcoma breakpoint region 1 antibody;Ewing sarcoma breakpoint region 1 protein antibody;Ewings sarcoma EWS Fli1 type 1 oncogene antibody;EWS antibody;EWS oncogene antibody;EWS RNA binding protein 1 antibody;EWS_HUMAN antibody;EWSR 1 antibody;Ewsr1 antibody;EWSR1 protein antibody;RNA binding protein EWS antibody;RNA-binding protein EWS antibody

SEQUENCE SIMILARITIES

Belongs to the RRM TET family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated; calmodulin-binding inhibits phosphorylation of Ser-266.; Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.

SUBCELLULAR LOCATION

Cytoplasm. Plasma membrane. Nucleus.

FUNCTION

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. It is one of 3 proteins in the FET protein family. The q22.2 region of chromosome 22 encodes the N-terminal transactivation domain of the EWS protein and that region may become joined to one of several other chromosomes which encode various transcription factors, see and the FET protein family. The expression of a chimeric protein with the EWS transactivation domain fused to the DNA binding region of a transcription factor generates a powerful oncogenic protein causing Ewing sarcoma and other members of the Ewing family of tumors. These translocations can occur due to chromoplexy, a burst of complex chromosomal rearrangements seen in cancer cells. The normal EWS gene encodes an RNA binding protein closely related to FUS (gene) and TAF15, all of which have been associated to amyotrophic lateral sclerosis.