F13A1 Mouse Monoclonal Antibody [16D3] (EM1901-38)

UNIPROT #

P00488

PROTEIN NAME

F13A1

SYNONYMS

bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody;Coagulation factor XIII A chain antibody;Coagulation factor XIII A1 polypeptide antibody;Coagulation factor XIII A1 subunit antibody;Coagulation factor XIII, A polypeptide antibody;Coagulation factor XIIIa antibody;F13A antibody;F13A_HUMAN antibody;F13a1 antibody;Factor XIIIA antibody;Fibrin stabilizing factor, A subunit antibody;Fibrinoligase antibody;FSF, A subunit antibody;Protein glutamine gamma glutamyltransferase A chain antibody;Protein-glutamine gamma-glutamyltransferase A chain antibody;TGase antibody;Transglutaminase A chain antibody;Transglutaminase, plasma antibody;Transglutaminase. plasma antibody

SEQUENCE SIMILARITIES

Belongs to the transglutaminase superfamily. Transglutaminase family.

POST-TRANSLATIONAL MODIFICATION

The activation peptide is released by thrombin.

SUBCELLULAR LOCATION

Secreted, cytoplasm.

FUNCTION

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin, and factors V, VIII, IX and X), which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Coagulation factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IXa, factor Xa, factor XIIa, or thrombin mediated proteolytic cleavage of Factor VII at Arg152-Ile153 generates Factor VIIa, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Coagulation factor XIII is a terminal effector in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, and the noncatalytic B subunits may serve as plasma carrier molecules.