Fibulin 5 Rabbit Polyclonal Antibody (ER1802-95)

UNIPROT #

Q9UBX5

PROTEIN NAME

Fibulin 5

SYNONYMS

ADCL2 antibody;ARCL1A antibody;ARMD3 antibody;Dance antibody;Developmental arteries and neural crest EGF like protein antibody;Developmental arteries and neural crest EGF-like protein antibody;EVEC antibody;Fbln5 antibody;FBLN5_HUMAN antibody;FIBL 5 antibody;FIBL-5 antibody;Fibulin-5 antibody;FLJ90059 antibody;UP50 antibody;Urine p50 protein antibody

SEQUENCE SIMILARITIES

Belongs to the fibulin family.

TISSUE SPECIFICITY

Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Extracellular matrix. Secreted.

FUNCTION

Fibulin proteins contribute to normal development of elastic fiber systems in various types of organs that require elasticity, such as vasculature, lung and skin. Fibulin-5 (EVEC, UP50, DANCE) is an integrin-binding extracellular matrix protein that mediates endothelial cell adhesion. Fibulin-5 is also a calcium-dependent elastin-binding protein that scaffolds cells to elastic fibers, thereby preventing elastinopathy in the skin, lung, and vasculature. The Arg-Gly-Asp (RGD) motif in Fibulin-5 interacts with cell surface integrins avb3, avb5 and a9b1, serves as an anchorage for elastic fibers to cells, and promotes organization of elastic fibers. The human Fibulin-5 gene maps to chromosome 14q32.12 and encodes a 488 amino acid protein.