FKBP52 Recombinant Rabbit Monoclonal Antibody [JG96-30] (ET7108-93)

UNIPROT #

Q02790

PROTEIN NAME

FKBP52

SYNONYMS

51 kDa FK506-binding protein antibody;52 kDa FK506 binding protein antibody;52 kDa FK506-binding protein antibody;52 kDa FKBP antibody;59 kDa immunophilin antibody;FK506 binding protein 4 antibody;FK506-binding protein 4 antibody;FKBP 4 antibody;FKBP 52 antibody;FKBP 59 antibody;FKBP-4 antibody;FKBP-52 antibody;FKBP4 antibody;FKBP4_HUMAN antibody;FKBP51 antibody;FKBP52 protein antibody;FKBP59 antibody;HBI antibody;Hsp 56 antibody;HSP binding immunophilin antibody;HSP-binding immunophilin antibody;Hsp56 antibody;Immunophilin FKBP52 antibody;N-terminally processed antibody;p52 antibody;p59 antibody;p59 protein antibody;Peptidyl prolyl cis trans isomerase antibody;Peptidyl-prolyl cis-trans isomerase FKBP4 antibody;Peptidylprolyl cis trans isomerase antibody;PPIase antibody;PPIase FKBP4 antibody;Rotamase antibody;T cell FK506 binding protein 59kD antibody

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by CK2 results in loss of HSP90 binding activity.

SUBCELLULAR LOCATION

Cytoplasm. Cytoskeleton. Microtubule. Mitochondrion. Nucleus.

FUNCTION

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.