FOXP1 Recombinant Rabbit Monoclonal Antibody [PD00-47] (HA721195)

UNIPROT #

Q9H334

PROTEIN NAME

FOXP1

SYNONYMS

12CC4 antibody;FLJ23741 antibody;Fork head related protein like B antibody;Forkhead box P1 antibody;Forkhead box protein P1 antibody;FOX P1 antibody;FOXP 1 antibody;foxp1 antibody;FOXP1_HUMAN antibody;Glutamine rich factor 1 antibody;hFKH1B antibody;HSPC215 antibody;MGC12942 antibody;MGC88572 antibody;MGC99551 antibody;QRF 1 antibody;QRF1 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Forkhead box P1 (FOXP1) is a transcription factor normally expressed in many cellular processes and plays an important role in development, specifically in human leukocyte populations. Expression of FOXP1 can be found in neoplastic and non-neoplastic tissues. Overexpression of FOXP1 has been observed in a subset of diffuse large B-cell lymphoma (DLBCL), and thus FOXP1 immunohistochemistry has been shown to be helpful in the subclassification of DLBCL. Diffuse large B-cell lymphoma (DLBCL) most likely represents different clinicopathologic entities, which are difficult to separate using standard technique. Diffuse large B-cell lymphoma (DLBCL) can be divided into the subtypes of germinal center B-cell–like (GCB), activated B-cell–like (ABC), and unclassified DLBCL. The GCB and ABC subtypes have different pathogenetic mechanisms that will impact the development of targeted therapies. Despite the robustness of gene expression profiling (GEP) in subclassifying DLBCL, GEP techniques are not applicable to the routine clinical practice due to the substantial time, technological expertise, and scarce resources required. Therefore, it is beneficial for the translational application of the GEP classification into protein expression by tumor cells to be developed through immunohistochemical (IHC) staining of formalin-fixed, paraffin-embedded tissues. Different approaches using immunophenotypic algorithms with small panels of antibody biomarkers have been developed to translate the robust information from molecular studies into a routine clinical platform, using antibodies against CD10, BCL6, MUM1/IRF4, GCET1, FoxP1, LMO2, and BCL2. Therefore, FoxP1 is useful in subclassification of DLBCL and a high cutoff (≥80%) for FoxP1 is needed to achieve high specificity for the ABC subtype.