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Fusion glycoprotein F0 Rabbit Polyclonal Antibody (ER1802-33)

Price: Regular price $315.00

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Catalog# ER1802-33

Rabbit Polyclonal to Fusion glycoprotein F0

Tested for

  • WB

  • ELISA

Reacts with

  • Avian avulavirus 1

Specifications

Product Type

Rabbit polyclonal primary

Product Name

Fusion glycoprotein F0 Rabbit Polyclonal Antibody (ER1802-33)

Immunogen

Synthetic peptide within newcastle disease virus fusion glycoprotein f0 aa 86-135 / 553.

Host

Rabbit

Positive Control

Fusion glycoprotein F0 transfected HEK293 cell.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069131

APPLICATION DILUTION

  • WB

  • 1:500-1,000

  • ELISA

  • 1:5,000-1:10,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

59 kDa

Isotype

IgG

TARGET

UNIPROT #

W8CLH7

PROTEIN NAME

Fusion glycoprotein F0

SYNONYMS

F antibody;Fusion glycoprotein F0 antibody;Protein F antibody;RSV Fusion (F) Glycoprotein antibody

SEQUENCE SIMILARITIES

Belongs to the paramyxoviruses fusion glycoprotein family.

SUBCELLULAR LOCATION

Host cell membrane. Virion membrane.

FUNCTION

During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.

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