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G6PD Rabbit Polyclonal Antibody (R1706-7)

Price: Regular price $315.00

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Catalog# R1706-7

Rabbit Polyclonal to G6PD

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

G6PD Rabbit Polyclonal Antibody (R1706-7)

Immunogen

Recombinant protein within human g6pd aa 218-404.

Host

Rabbit

Positive Control

A549, Hela, MCF-7, PC-12, mouse spleen tissue lysate, human tonsil tissue, human colon cancer tissue, human spleen tissue, mouse testis tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073435

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

59 kDa

Isotype

IgG

TARGET

UNIPROT #

P11413

PROTEIN NAME

G6PD

SYNONYMS

G6PD antibody;G6PD_HUMAN antibody;G6PD1 antibody;G6pdx antibody;Glucose 6 phosphate 1 dehydrogenase antibody;Glucose 6 phosphate dehydrogenase antibody;Glucose 6 phosphate dehydrogenase, G6PD antibody;Glucose-6-phosphate 1-dehydrogenase antibody;MET19 antibody;POS10 antibody;Zwf1p antibody

SEQUENCE SIMILARITIES

Belongs to the glucose-6-phosphate dehydrogenase family.

TISSUE SPECIFICITY

Isoform Long is found in lymphoblasts, granulocytes and sperm.

POST-TRANSLATIONAL MODIFICATION

Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus. Membrane.

FUNCTION

Glucose-6-phosphate 1-dehydrogenase (G6PD) plays an important role in the pentose phosphate pathway. It is a member of the glucose-6-phosphate dehydrogenase family of proteins. G6PD is a ubiquitous enzyme that produces pentose sugars for nucleic acid synthesis, but is also involved in carbohydrate degradation, as it is one of the main producers of NADPH reducing power. G6PD has NADP as a co-factor and structural element. It can be found as a homodimer or homotetramer, and is primarily detected in lymphoblasts, granulocytes and sperm. Defects in G6PD can cause chronic non-spherocytic hemolytic anemia (CNSHA), especially in areas in which malaria is an epidemic. Individuals with a high level of G6PD-deficiency are at higher risk of acute hemolytic attacks.

CITATIONS

  • Xu, X., Wang, L., Zang, Q., Li, S., Li, L., Wang, Z., He, J., Qiang, B., Han, W., Zhang, R., Peng, X., & Abliz, Z.

    Rewiring of purine metabolism in response to acidosis stress in glioma stem cells. Cell death & disease, 12(3), 277.

  • G6PD drives glioma invasion by regulating SQSTM1 protein stability

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