G6PD Rabbit Polyclonal Antibody (R1706-7)
Catalog# R1706-7
Rabbit Polyclonal to G6PD
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WB
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IF-Cell
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: A549 Lane 2: Hela Lane 3: MCF-7 Lane 4: PC-12 Lane 5: Mouse spleen
Specifications
Product Type
Rabbit polyclonal primary
Product Name
G6PD Rabbit Polyclonal Antibody (R1706-7)
Immunogen
Recombinant protein within human g6pd aa 218-404.
Host
Rabbit
Positive Control
A549, Hela, MCF-7, PC-12, mouse spleen tissue lysate, human tonsil tissue, human colon cancer tissue, human spleen tissue, mouse testis tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:1,000-1:2,000
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IF-Cell
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1:50-1:200
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
59 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
G6PD
SYNONYMS
G6PD antibody;G6PD_HUMAN antibody;G6PD1 antibody;G6pdx antibody;Glucose 6 phosphate 1 dehydrogenase antibody;Glucose 6 phosphate dehydrogenase antibody;Glucose 6 phosphate dehydrogenase, G6PD antibody;Glucose-6-phosphate 1-dehydrogenase antibody;MET19 antibody;POS10 antibody;Zwf1p antibody
SEQUENCE SIMILARITIES
Belongs to the glucose-6-phosphate dehydrogenase family.
TISSUE SPECIFICITY
Isoform Long is found in lymphoblasts, granulocytes and sperm.
POST-TRANSLATIONAL MODIFICATION
Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.
SUBCELLULAR LOCATION
Cytoplasm. Nucleus. Membrane.
FUNCTION
Glucose-6-phosphate 1-dehydrogenase (G6PD) plays an important role in the pentose phosphate pathway. It is a member of the glucose-6-phosphate dehydrogenase family of proteins. G6PD is a ubiquitous enzyme that produces pentose sugars for nucleic acid synthesis, but is also involved in carbohydrate degradation, as it is one of the main producers of NADPH reducing power. G6PD has NADP as a co-factor and structural element. It can be found as a homodimer or homotetramer, and is primarily detected in lymphoblasts, granulocytes and sperm. Defects in G6PD can cause chronic non-spherocytic hemolytic anemia (CNSHA), especially in areas in which malaria is an epidemic. Individuals with a high level of G6PD-deficiency are at higher risk of acute hemolytic attacks.
CITATIONS
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G6PD drives glioma invasion by regulating SQSTM1 protein stability
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WB
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Human
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Citation
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Xu, X., Wang, L., Zang, Q., Li, S., Li, L., Wang, Z., He, J., Qiang, B., Han, W., Zhang, R., Peng, X., & Abliz, Z.
Rewiring of purine metabolism in response to acidosis stress in glioma stem cells. Cell death & disease, 12(3), 277.
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WB
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Human
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Citation
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