GABRB3 Rabbit Polyclonal Antibody (HA500090)

UNIPROT #

P28472

PROTEIN NAME

GABA A Receptor beta 3

SYNONYMS

ECA5 antibody;GABA alpha receptor beta-2 subunit antibody;GABA(A) receptor subunit beta-3 antibody;GABAA receptor beta 3 subunit antibody;GABAA receptor subunit beta 3 antibody;GABR B3 antibody;Gabrb3 antibody;Gamma aminobutyric acid (GABA) A receptor beta 3 antibody;Gamma aminobutyric acid receptor subunit beta 3 antibody;Gamma-aminobutyric acid receptor subunit beta-3 antibody;GBRB3_HUMAN antibody;MGC9051 antibody

SUBCELLULAR LOCATION

Plasma membrane, Cell membrane, Cytoplasmic vesicle membrane.

FUNCTION

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity. The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Plays an important role in somatosensation and in the production of antinociception.