Galectin 3 Recombinant Rabbit Monoclonal Antibody [JF39-10] (ET1702-48)
Catalog# ET1702-48
Rabbit Monoclonal to Galectin 3
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WB
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IF-Cell
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IF-Tissue
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FC
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: NIH/3T3 cell lysate
Lane 2: Hela cell lysate
Lane 3: THP-1 cell lysate
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Galectin 3 Recombinant Rabbit Monoclonal Antibody [JF39-10] (ET1702-48)
Immunogen
Synthetic peptide within human galectin 3 aa 1-49 / 250.
Host
Rabbit
Positive Control
NIH/3T3 cell lysate, Hela cell lysate, THP-1 cell lysate, HeLa, human thyroid carcinoma tissue, human colon tissue, rat bladder tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JF39-10
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IF-Cell
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1:50-1:200
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IF-Tissue
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1:50-1:200
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FC
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1:1,000
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IHC-P
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1:200-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 26 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Galectin 3
SYNONYMS
35 kDa lectin antibody;Carbohydrate binding protein 35 antibody;Carbohydrate-binding protein 35 antibody;CBP 35 antibody;CBP35 antibody;Gal-3 antibody;GAL3 antibody;Galactose-specific lectin 3 antibody;Galactoside-binding protein antibody;GALBP antibody;Galectin 3 internal gene,included antibody;Galectin-3 antibody;Galectin 3 antibody;Galectin3 antibody;GALIG antibody;GBP antibody;IgE binding protein antibody;IgE-binding protein antibody;L 31 antibody;L 34 antibody;L-31 antibody;L-34 galactoside-binding lectin antibody;L31 antibody;Laminin-binding protein antibody;Lectin L-29 antibody;Lectin, galactose binding, soluble 3 antibody;LEG3_HUMAN antibody;LGALS2 antibody;LGALS3 antibody;MAC 2 antigen antibody;Mac-2 antibody;Mac-2 antigen antibody;MAC2 antibody;Macrophage galactose-specific lectin antibody;MGC105387 antibody
TISSUE SPECIFICITY
A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
SUBCELLULAR LOCATION
Nucleus, Secreted, Cytoplasm.
FUNCTION
Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of β1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn's disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.
CITATIONS
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Chen Zhenzhen,et al
Effects of Three Kinds of Carbohydrate Pharmaceutical Excipients-Fructose, Lactose and Arabic Gum on Intestinal Absorption of Gastrodin through Glucose Transport Pathway in Rats
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WB
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Rat
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Citation
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