Galectin 7 Recombinant Rabbit Monoclonal Antibody [JB38-11] (ET7107-54)

UNIPROT #

P47929

PROTEIN NAME

Galectin 7

SYNONYMS

Gal-7 antibody;GAL7 antibody;Galectin 7B antibody;Galectin-7 antibody;HKL-14 antibody;Human keratinocyte lectin 14 antibody;Keratinocyte lectin 14 antibody;Lectin galactoside binding soluble 7 antibody;Lectin, galactoside binding, soluble, 7B antibody;LEG7_HUMAN antibody;LGALS7 antibody;LGALS7A antibody;LGALS7B antibody;P53 induced protein 1 antibody;p53-induced gene 1 protein antibody;Pi7 antibody;PIG1 antibody;TP53I1 antibody

TISSUE SPECIFICITY

Mainly expressed in stratified squamous epithelium.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus. Secreted.

FUNCTION

Galectin-7 is a protein that in humans is encoded by the LGALS7 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). It is moderately repressed by retinoic acid. The protein was found mainly in stratified squamous epithelium. The antigen localized to basal keratinocytes, although it was also found, albeit at lower levels, in the suprabasal layers where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell–cell and/or cell–matrix interactions necessary for normal growth control.