gamma Synuclein Recombinant Rabbit Monoclonal Antibody [JM90-32] (ET1705-48)

UNIPROT #

O76070

PROTEIN NAME

gamma Synuclein

SYNONYMS

BCSG1 antibody;Breast cancer specific gene 1 protein antibody;Breast cancer specific protein 1 antibody;Breast cancer-specific gene 1 protein antibody;Gamma synuclein antibody;Gamma-synuclein antibody;Persyn antibody;PRSN antibody;SNCG antibody;SR antibody;Synoretin antibody;Synuclein gamma antibody;synuclein, gamma (breast cancer-specific protein 1) antibody;SYUG_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the synuclein family.

TISSUE SPECIFICITY

Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.

SUBCELLULAR LOCATION

Cytoplasm. Cytoskeleton. Centrosome.

FUNCTION

Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. Synuclein-gamma is a member of the synuclein family of proteins, which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development. Gamma-synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. It is also detected in the brain, ovarian tumors, and in the olfactory epithelium. Gamma-synuclein is the least conserved of the synuclein proteins. Gamma-Synucleins expression in breast tumors is a marker for tumor progression as mammalian gamma-synuclein was first identified as breast cancer-specific gene 1 (BCSG1). A change in the expression of gamma-synuclein has been observed in the retina of patients with Alzheimer's disease. The normal cellular function of gamma-synuclein remains unknown.