GANAB Recombinant Rabbit Monoclonal Antibody [PSH01-53] (HA721696)

UNIPROT #

Q14697

PROTEIN NAME

GANAB

SYNONYMS

Alpha glucosidase II alpha subunit antibody;Alpha-glucosidase 2 antibody;G2AN antibody;GANAB antibody;GANAB_HUMAN antibody;Glu II antibody;Glucosidase alpha neutral AB antibody;Glucosidase II alpha antibody;Glucosidase II subunit alpha antibody;GluII antibody;KIAA0088 antibody;Neutral alpha glucosidase AB antibody;Neutral alpha glucosidase AB precursor antibody;Neutral alpha-glucosidase AB antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum, Golgi apparatus.

FUNCTION

This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. atalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.