GART Recombinant Rabbit Monoclonal Antibody [SC66-02] (ET1610-68)

UNIPROT #

P22102

PROTEIN NAME

GART

SYNONYMS

5'-phosphoribosylglycinamide transformylase antibody;AIR synthase antibody;AIRS antibody;GAR transformylase antibody;GARS antibody;GART antibody;GARTF antibody;Glycinamide ribonucleotide synthetase antibody;MGC47764 antibody;PAIS antibody;PGFT antibody;Phosphoribosyl-aminoimidazole synthetase antibody;Phosphoribosylglycinamide formyltransferase antibody;Phosphoribosylglycinamide formyltransferase phosphoribosylglycinamide synthetase phosphoribosylaminoimidazole synthetase antibody;Phosphoribosylglycinamide formyltransferase, EC 2.1.2.29 antibody;Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase antibody;Phosphoribosylglycinamide synthetase antibody;PRGS antibody;PUR2_HUMAN antibody;Trifunctional purine biosynthetic protein adenosine 3 antibody

SEQUENCE SIMILARITIES

In the N-terminal section; belongs to the GARS family.; In the central section; belongs to the AIR synthase family.; In the C-terminal section; belongs to the GART family.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Membrane.

FUNCTION

Purines are critical for energy metabolism, cell signaling and cell reproduction and also function as precursors for coenzymes, energy transfer molecules, regulatory factors and proteins involved in RNA and DNA synthesis. GART (GAR transformylase), also referred to as AIRS, GARS, PAIS, PGFT, PRGS or GARTF, is 1,010 amino acids in length and is a key folate-dependent trifunctional enzyme with phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase and AICAR (phosphoribosylaminoimidazole synthetase) activity required for de novo purine biosynthesis. Cancer cells require considerable amounts of purines to sustain their accelerated growth and GART is, therefore, a target for cancer chemotherapy. GART is highly conserved in vertebrates. Two isoforms of GART are expressed due to alternative splicing events.