GATA1 Recombinant Rabbit Monoclonal Antibody [JA10-32] (ET1704-41)

UNIPROT #

P15976

PROTEIN NAME

GATA1

SYNONYMS

Anemia, X-linked, without thrombocytopenia, included antibody;ERYF 1 antibody;Eryf1 antibody;Erythroid transcription factor antibody;Erythrold transcription factor 1 antibody;GATA 1 antibody;GATA binding factor 1 antibody;GATA binding protein 1 (globin transcription factor 1) antibody;GATA binding protein 1 antibody;GATA-1 antibody;GATA-binding factor 1 antibody;GATA1 antibody;GATA1_HUMAN antibody;GF 1 antibody;GF-1 antibody;GF1 antibody;Globin transcription factor 1 antibody;NF E1 antibody;NF E1 DNA binding protein antibody;NF-E1 DNA-binding protein antibody;NFE 1 antibody;NFE1 antibody;Nuclear factor erythroid 1 antibody;Transcription factor GATA1 antibody;XLANP antibody;XLTDA antibody;XLTT antibody

TISSUE SPECIFICITY

Erythrocytes.

POST-TRANSLATIONAL MODIFICATION

Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137 (By similarity).; Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity (By similarity).; Acetylated at 2 conserved lysine-rich motifs by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo (By similarity). Acetylated on Lys-233, Lys-245 Lys-246 by EP300.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is widely expressed throughout vertebrate species. In humans and mice, it is encoded by the GATA1 and Gata1 genes, respectively. These genes are located on the X chromosome in both species. GATA1 regulates the expression (i.e. formation of the genes' products) of an ensemble of genes that mediate the development of red blood cells and platelets. Its critical roles in red blood cell formation include promoting the maturation of precursor cells, e.g. erythroblasts, to red blood cells and stimulating these cells to erect their cytoskeleton and biosynthesize their oxygen-carrying components viz., hemoglobin and heme. GATA1 plays a similarly critical role in the maturation of blood platelets from megakaryoblasts, promegakaryocytes, and megakaryocytes; the latter cells then shed membrane-enclosed fragments of their cytoplasm, i.e. platelets, into the blood. Reduced levels of GATA1 due to reductions in the translation of GATA1 mRNA into its transcription factor product are associated with promoting the progression of myelofibrosis, i.e. a malignant disease that involves the replacement of bone marrow cells by fibrous tissue and extramedullary hematopoiesis, i.e. the extension of blood cell-forming cells to sites outside of the bone marrow.