GDF3 Recombinant Rabbit Monoclonal Antibody [JE38-51] (HA722339)

UNIPROT #

Q9NR23

PROTEIN NAME

GDF3

SYNONYMS

C78318 antibody;ecat9 antibody;GDF 3 antibody;GDF-3 antibody;GDF3 antibody;GDF3_HUMAN antibody;Growth differentiation factor 3 antibody;Growth/differentiation factor 3 antibody;KFS3 antibody;MCOP7 antibody;MCOPCB6 antibody;MGC123990 antibody;MGC123991 antibody;RGD1564178 antibody;Vgr 2 antibody;Vgr2 antibody

SUBCELLULAR LOCATION

Secreted, Cytoplasm.

FUNCTION

Growth differentiation factor-3 (GDF3), also known as Vg-related gene 2 (Vgr-2) is protein that in humans is encoded by the GDF3 gene. GDF3 belongs to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members including Vg1 (found in frogs) and GDF1. GDF3 is a bi-functional protein that has some intrinsic activity and also modulate other TGF-β superfamily members, e.g. potentiates the activity of NODAL. It may also inhibit other TGF-β superfamily members (i.e. BMPs), thus regulating the balance between different modes of TGF-beta signaling. It has been shown to negatively and positively control differentiation of embryonic stem cells in mice and humans. This molecule plays a role in mesoderm and definitive endoderm formation during the pre-gastrulation stages of development. Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.