GEF H1 Recombinant Rabbit Monoclonal Antibody [JG36-46] (ET7108-34)

UNIPROT #

Q92974

PROTEIN NAME

GEF H1

SYNONYMS

AA408978 antibody;ARHG2 antibody;ARHG2_HUMAN antibody;ARHGEF 2 antibody;ARHGEF-2 antibody;ARHGEF2 antibody;GEF antibody;GEF H1 antibody;GEF-H1 antibody;GEFH1 antibody;Guanine nucleotide exchange factor H1 antibody;KIAA0651 antibody;Lbcl1 antibody;Lfc antibody;LFP40 antibody;MGC95068 antibody;Microtubule-regulated Rho-GEF antibody;mKIAA0651 antibody;P40 antibody;Proliferating cell nucleolar antigen p40 antibody;Protein GEF-H1 antibody;Rho guanine nucleotide exchange factor 2 antibody;rho/rac guanine nucleotide exchange factor (GEF) 2 antibody;rho/rac guanine nucleotide exchange factor 2 antibody;rho/rac guanine nucleotide exchange factor antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Ser-886 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner.

SUBCELLULAR LOCATION

Ruffle membrane, cytoskeleton, spindle, Golgi apparatus, Cytoplasm, tight junction, Cytoplasmic vesicle.

FUNCTION

Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA.