Gemin 1 Recombinant Rabbit Monoclonal Antibody [JG38-19] (ET7108-63)

UNIPROT #

Q16637

PROTEIN NAME

Gemin 1

SYNONYMS

BCD541 antibody;Component of gems 1 antibody;Gemin 1 antibody;Gemin-1 antibody;OTTHUMP00000125198 antibody;OTTHUMP00000223567 antibody;OTTHUMP00000223568 antibody;OTTHUMP00000224066 antibody;OTTHUMP00000226924 antibody;SMA 1 antibody;SMA 2 antibody;SMA 3 antibody;SMA 4 antibody;SMA antibody;SMA@ antibody;SMA1 antibody;SMA2 antibody;SMA3 antibody;SMA4 antibody;SMN antibody;SMN_HUMAN antibody;SMN1 antibody;SMN2 antibody;SMNT antibody;Survival motor neuron protein antibody;Survival of motor neuron 1, telomeric antibody;T-BCD541 antibody

SEQUENCE SIMILARITIES

Belongs to the SMN family.

TISSUE SPECIFICITY

Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).